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The Drug Discovery Top Ten
The Industry’s Most Innovative and Powerful Drug Discovery Tools
1. Transcreener™ HTS, Bellbrook Labs. 
 
 
Users of Promega ADP-Glo or DiscoverX ADP-Quest will want to strongly consider Transcreener as a superior alternative. Rather than indirect detection using several coupled enzymes assays, Transcreener uses a nucleotide-specific antibody to directly detect the pathway product. Transcreener is also 20-600-fold more sensitive than ADP-Glo or ADP-Quest. It can be used in TR-FRET, FI and FP modes.  To receive a whitepaper with more details about Transcreener, click here

 
2. QuantiGene® Plex Assay, Affymetrix
 
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Do you run a lot of QPCR for target validation or assay readout?  Finding it tedious doing RNA preps on a large scale? The bDNA-based QuantiGene Plex Assay will vastly reduce your workload because no nucleic acid prep is required! Performed on the Luminex platform, QuantiGene is capable of quantifying up to 80 targets in a single well and can be performed directly on whole blood, cultured cells and even FFPE samples. Additionally, QuantiGene achieves superior precision to PCR. Get the whitepaper.
 
3. Immunome Array, Raybiotech.
 
 

The Immunome Array from Raybiotech is the world’s first fully functional protein array.  The array consists of 1,600 proteins bound to a microscope slide. Patented technology ensures that only full-length, properly folded proteins are represented. The arrays can be used for a variety of applications including, especially, screening for autoantibodies in patient serum.  But also, they can be used for on-array measurement of kinase-inhibition, protein-protein, or protein-DNA interaction. Learn more
 
4. PrimeFlow™ RNA flow cytometry, Affymetrix
 
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Flow cytometry has long been one of the most important methods in drug development, especially for blood cancers and inflammatory diseases. But it has previously been limited to the study of protein targets. PrimeFlow, arguably the most important innovation in flow in ten years, now permits researchers to examine the expression of RNA transcripts at the single cell level. As such, it unlocks massive potential to study potential drug discovery targets without the need for time-consuming and costly antibody development. Watch the video
 
5. MyGo Mini thermocycler, IT-IS Life Sciences
 

Want qPCR with style? The MyGo Mini is the world's most compact real-time PCR instrument, with no moving parts for silent operation and maximum reliability. The tech specs are as good as high end instruments costing three to four times as much. Only 12cm across, it occupies a tiny footprint on your bench. Unlike most lab instruments, it’s compatible with a Mac.It’s available in four colors of your choosing, so you can choose one that matches your personality. And to top it off, the MyGo is one the cheapest real-time instruments you’ll find. Style and substance. Learn more.
 
6. TLR reporter cell lines and ligands, InvivoGen.
 

Toll Like Receptors are one of the hottest targets, particularly for cancer, rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus (SLE). Several compounds are already under clinical evaluation, with a focus on TLR7 and TLR9 activators in infection and cancer, and inhibitors of TLR2, TLR4, TLR7 and TLR9 for inflammatory diseases and sepsis. InvivoGen provides a comprehensive set of TLR reporter and TLR expressing cells. These handy cells enable efficient monitoring of TLR activity using an NF-κB/AP-1-inducible SEAP (secreted embryonic alkaline phosphatase) reporter system. InvivoGen is also the best source for ultrapure TLR agonists and antagonists.
 
7. ChemiScreen™ Ready-to-Assay GPCR cell lines and membrane preps, Eurofins.  
 

GPCRs remain one of the two largest target types for drug discovery. Eurofins (formerly Merck-Millipore Drug Discovery) has been rated as the top screening service provider academic labs and pharma. Now, Eurofins is offering the proprietary tools it has used internally for direct sale to researchers. These include Calcium-optimized cell lines, Membrane Preps and Ready-to-Use cells for well over one hundred different GPCR targets. If you are looking to screen GPCRs, Eurofins is probably your fastest track to benchwork.
 
8. Bioactive screening libraries, SelleckChem
 

Many drug discovery projects start with focused libraries of known biologically active compounds. SelleckChem has assembled numerous off-the-shelf libraries specific for individual therapeutic areas. These range from common applications such as Kinases and GPCRs to specialties like diabetes or autophagy. It’s very useful that SelleckChem operates probably the industry’s best and most comprehensive website, with extensive technical data on every library or compound. Tip: Search for your compounds on www.selleckchem.com, but email info@JLresearch.com.au for a guaranteed discounted quote.
 
9. Iuvo Immunocytochemistry 3D High Content Screening Assay, Bellbrook Labs
 

Looking to perform a complex high content screen, such as cell motility in 3D, or cell viability or apoptosis in realtime?  The Iuvo 3D Assay Slide Device consists of Microconduit channels mounted onto standard microscope slides that can be used with any inverted microscope instead of requiring a high-end automated HCA instrument. The microchannel design in the 3D Assay Slide allows immunostaining in situ even in dense matrices like Matrigel™.
 
10. TBC
 
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