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Anti-ZO-1 eFluor® 570 100 ug

Anti-ZO-1 eFluor® 570 100 ug

Quick Overview:

Anti-ZO-1 eFluor® 570 100 ug

Product Code: 41-9776-82

  • Details

    The monoclonal antibody R26.4C recognizes the tight junction protein 1, ZO-1 (zona occludens) of rat, mouse, canine, and porcine. ZO-1 is a member of the MAGUK family of tight junction associated scaffolding proteins, each containing a PDZ, SH3 and guanylate kinase-like (GUK) domain. ZO-1 is an integral member of the tight junction complex which forms a barrier to paracellular movement of substances, separating apical and basolateral fluids in relation to the epithelial cell layer. ZO-1 forms complexes with family members ZO-2, ZO-3, as well as occludin, cingulin, claudin-1-8, actin, alpha-catenin, the Ras-effector molecule AF-6, ZONAB, Apg-2, and the junctional adhesion molecules (JAM)-A-C. ZO-1 is thought to anchor the actin cytoskeleton to the tight junction. ZO-1 and ZO-2 have been shown to regulate cell cycle and proliferation with recent evidence highlighting the down-regulation of ZO-1 and ZO-2 with cancer progression.
  • Additional Information

    SKU 41-9776-82
    Name Anti-ZO-1 eFluor® 570 100 ug
    Size 100 ug
    Product Type ICC/IHC Reagents
    Datasheet View Datasheet
    Clone R26.4C
    Host species Rat
    Supplier eBioscience
    Applications Immunocytochemistry, Immunohistochemical Staining of Frozen Tissue Sections, Microscopy
    Species reactivity (expected) Canine, Mouse, Rat
    General Readings Brennan K, Offiah G, McSherry EA, Hopkins AM. Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol. 2010;2010:460607. Epub 2009 Nov 15.

    Wittchen ES, Haskins J, Stevenson BR. Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem. 1999 Dec 3;274(49):35179-85.

    Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 1986 Sep;103(3):755-66.
    Storage +4C