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Mouse IL-17E (IL-25) Single-Use ELISA RSG Standard 4 pack

Mouse IL-17E (IL-25) Single-Use ELISA RSG Standard 4 pack

Quick Overview:

Mouse IL-17E (IL-25) Single-Use ELISA RSG Standard 4 pack

Product Code: 39-9175-65

  • Details

    IL-17E, or IL-25, was first identified as an IL-17 family member on the basis of sequence homology. It was originally believed to be a Th2 cytokine based on the detection of mRNA transcripts in polarized Th2 cells, but expression was later observed in epithelial cells, eosinophils, and mast cells. Later studies confirmed the role of IL-17E as a potent inducer of type 2 immune responses. IL-17E signaling induces the differentiation of CD4+ T cells towards the Th2 lineage and upregulates expression of Th2 cytokines such as IL-4, IL-5, and IL-13. Administration of IL-17E also promotes symptoms of allergic asthma, such as eosinophil infiltration, airway hyperreactivity, and high circulating levels of IgE. IL-17E binds to IL-17BR, a receptor shared with IL-17B, and activates NF kappa-B pathways.
  • Additional Information

    SKU 39-9175-65
    Name Mouse IL-17E (IL-25) Single-Use ELISA RSG Standard 4 pack
    Size 4 pack
    Product Type Uncoated ELISA & support pdts
    Datasheet View Datasheet
    Supplier eBioscience
    Applications ELISA, ELISA Recombinant Standard
    Species reactivity (expected) Mouse
    General Readings Dong C. Regulation and pro-inflammatory function of interleukin-17 family cytokines. Immunol Rev. 2008 Dec;226:80-6.

    Kang CM, Jang AS, Ahn MH, Shin JA, Kim JH, Choi YS, Rhim TY, Park CS. Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles. Am J Respir Cell Mol Biol. 2005 Sep;33(3):290-6.

    Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A, Saito Y, Iwamoto I. Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation. Blood. 2003 May 1;101(9):3594-6.

    Hurst SD, Muchamuel T, Gorman DM, Gilbert JM, Clifford T, Kwan S, Menon S, Seymour B, Jackson C, Kung TT, Brieland JK, Zurawski SM, Chapman RW, Zurawski G, Coffman RL. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol. 2002 Jul 1;169(1):443-53.
    Storage -80C