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Human TGF beta 1 Single-Use ELISA RSG Standard (2nd Generation) 4 pack

Human TGF beta 1 Single-Use ELISA RSG Standard (2nd Generation) 4 pack

Quick Overview:

Human TGF beta 1 Single-Use ELISA RSG Standard (2nd Generation) 4 pack

Product Code: 39-8343-65

  • Details

    Transforming Growth Factor beta (TGF beta) is a pleiotropic cytokine which exists in five isoforms, known as TGF beta 1-5, with homologies of 70-80% and no homology to TGF alpha. TGF beta 1 is the most abundant isoform and is ubiquitously expressed, while other isoforms are expressed in a more restricted manner. TGF beta 1 is highly conserved, with 100% sequence homology between the human, simian, bovine, porcine, and chicken proteins and 99% homology between the human and murine proteins. It is highly expressed in platelets and also produced by macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells.

    TGF beta 1 is synthesized as a long precursor polypeptide, which is cleaved to yield the mature protein and the Latency Associated Peptide (LAP). LAP and mature TGF beta 1 remain non-covalently associated through secretion, forming homodimers known as the Small Latent Complex (SLC). Secretion can be induced by steroids, retinoids, EGF, NGF, vitamin D3, and IL-1. The bioactivity of mature TGF beta 1 is dependent on its release from LAP by conformational changes and proteolytic processing. Its activities include inhibition of cell growth in epithelial cells, endothelial cells, fibroblasts, neurons, lymphoid cells, and other hematopoietic cell types. TGF beta 1 also inhibits the proliferation of T cells and NK cells, downregulates the activities of activated macrophages, and blocks the anti-tumor activity of IL-2 – bearing lymphokine-activated killer (LAK) cells. Recently, TGF beta 1 has been found to have a critical role in the development of regulatory T cells and act as a costimulatory factor for expression of Foxp3. Dendritic cells exposed to tumors have been reported to secrete TGF beta 1 and stimulate the differntiation of CD4+CD25+ Treg cells from peripheral CD4+CD25- progeny. TGF beta 1-induced regulatory T cells have been termed iTreg.
  • Additional Information

    SKU 39-8343-65
    Name Human TGF beta 1 Single-Use ELISA RSG Standard (2nd Generation) 4 pack
    Size 4 pack
    Product Type Uncoated ELISA & support pdts
    Datasheet View Datasheet
    Supplier eBioscience
    Applications Cytokine Bioassays, ELISA, ELISA Recombinant Standard, Functional Assays
    Species reactivity (expected) Human
    General Readings Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle P, Neurath MF. TGF-beta – induced Foxp3+ regulatory T cells suppress Th1-mediated experimental colitis. Gut. 2006 May;55(5):671-80.

    Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4572-7.

    Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors. 1993;8(1):1-9.

    Miyazono K, Heldin CH. Structure, function and possible clinical application of transforming growth factor-beta. J Dermatol. 1992 Nov;19(11):644-7
    Storage -80C