Serving Australia and NZ
1300 543 373
Return to Previous Page

Human MMP-9 Platinum ELISA 10 x 96 tests

Human MMP-9 Platinum ELISA 10 x 96 tests

Quick Overview:

Human MMP-9 Platinum ELISA 10 x 96 tests

Product Code: BMS2016/2TEN

  • Details

    The human MMP-9 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human MMP-9. The human MMP-9 ELISA is for in vitro diagnostic use. Not for use in therapeutic procedures.

    MMP-9 is a Zn+2 dependent endopeptidase, synthesized and secreted in monomeric form as zymogen. The structure is almost similar to MMP2, another member of matrixmetalloproteinase family.

    Like other proteolytic enzymes, MMP-9 is first synthesized as inactive proenzyme or zymogens. Activation of proMMP-9 is mediated by plasminogen activator/plasmin (PA/plasmin) system. The regulation of MMP-9 activity is also controlled through TIMP-3.

    MMP-9 plays an important role in tumor invasion, angiogenesis and metastasis. Increased levels of MMP-9 have been demonstrated in colorectal cancer, in acute leukemia, breast cancer, human melanoma and bladder cancer. MMP-9 potentiates pulmonary metastasis formation and glioma invasion. Apart from its function in tumor formation and spread, MMP-9 with its destructive effects is in close association with lung diseases and asthma. Leukocyte recruitment to the central nervous system MMP-9 means an involvement in the pathogenesis of multiple sclerosis. MMP-9 has a crucial role in reproductive endocrinology and shows a changed expression pattern after myocardial infarction.
  • Additional Information

    SKU BMS2016/2TEN
    Name Human MMP-9 Platinum ELISA 10 x 96 tests
    Size 10 x 96 tests
    Product Type Platinum ELISAs
    Datasheet View Datasheet
    Supplier eBioscience
    Applications ELISA
    Species reactivity (expected) Human
    General Readings Atkinson,J.J.; Senior,R.M.. Matrix metalloproteinase-9 in lung remodeling. Am.J.Respir.Cell Mol.Biol. 2003;28:12-24. (Link)

    Kelly,E.A.; Jarjour,N.N.. Role of matrix metalloproteinases in asthma. Curr.Opin.Pulm.Med. 2003;9:28-33. (Link)

    Fridman,R.; Toth,M.; Chvyrkova,I.; Meroueh,S.O.; Mobashery,S.. Cell surface association of matrix metalloproteinase-9 (gelatinase B). Cancer Metastasis Rev. 2003;22:153-166. (Link)

    Ohbayashi,H.; Shimokata,K.. Matrix metalloproteinase-9 and airway remodeling in asthma. Curr.Drug Targets.Inflamm.Allergy 2005;4:177-181. (Link)

    Chakraborti,S.; Mandal,M.; Das,S.; Mandal,A.; Chakraborti,T.. Regulation of matrix metalloproteinases: an overview. Mol.Cell Biochem. 2003;253:269-285. (Link)

    John,A.; Tuszynski,G.. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol.Oncol.Res. 2001;7:14-23. (Link)

    Klein,G.; Vellenga,E.; Fraaije,M.W.; Kamps,W.A.; de Bont,E.S.. The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia. Crit Rev.Oncol.Hematol. 2004;50:87-100. (Link)

    Kanayama,H.. Matrix metalloproteinases and bladder cancer. J.Med.Invest 2001;48:31-43. (Link)

    Van den Steen,P.E.; Dubois,B.; Nelissen,I.; Rudd,P.M.; Dwek,R.A.; Opdenakker,G.. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev.Biochem.Mol.Biol. 2002;37:375-536. (Link)

    Corbel,M.; Boichot,E.; Lagente,V.. Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury. Braz.J.Med.Biol.Res. 2000;33:749-754. (Link)

    Ohbayashi,H.. Matrix metalloproteinases in lung diseases. Curr.Protein Pept.Sci. 2002;3:409-421. (Link)

    Nakada,M.; Okada,Y.; Yamashita,J.. The role of matrix metalloproteinases in glioma invasion. Front Biosci. 2003;8:e261-e269. (Link)

    Owen,J.L.; Iragavarapu-Charyulu,V.; Lopez,D.M.. T cell-derived matrix metalloproteinase-9 in breast cancer: friend or foe?. Breast Dis. 2004;20:145-153. (Link)

    Zucker,S.; Vacirca,J.. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 2004;23:101-117. (Link)

    Creemers,E.E.; Cleutjens,J.P.; Smits,J.F.; Daemen,M.J.. Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?. Circ.Res. 2001;89:201-210. (Link)

    Sellebjerg,F.; Sorensen,T.L.. Chemokines and matrix metalloproteinase-9 in leukocyte recruitment to the central nervous system. Brain Res.Bull. 2003;61:347-355. (Link)

    Shah,B.H.; Catt,K.J.. Matrix metalloproteinases in reproductive endocrinology. Trends Endocrinol.Metab 2004;15:47-49. (Link)

    Thompson,M.M.; Squire,I.B.. Matrix metalloproteinase-9 expression after myocardial infarction: physiological or pathological?. Cardiovasc.Res. 2002;54:495-498. (Link)

    Corbel,M.; Belleguic,C.; Boichot,E.; Lagente,V.. Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis. Cell Biol.Toxicol. 2002;18:51-61. (Link)
    Storage +4C