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Human sCD40 Platinum ELISA 96 tests

Human sCD40 Platinum ELISA 96 tests

Quick Overview:

Human sCD40 Platinum ELISA 96 tests

Product Code: BMS265

  • Details

    The human sCD40 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD40. The human sCD40 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

    CD40 is a 48 kD type I glycoprotein and a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
  • Additional Information

    SKU BMS265
    Name Human sCD40 Platinum ELISA 96 tests
    Size 96 tests
    Product Type Platinum ELISAs
    Datasheet View Datasheet
    Supplier eBioscience
    Applications ELISA
    Species reactivity (expected) Human
    General Readings Laytragoon-Lewin,N.. Programmed cell death: the influence of CD40, CD95 (Fas or Apo-I) and their ligands. Med.Oncol. 1998;15:15-19. (Link)

    Huang,W.X.; Huang,P.; Hillert,J.. Systemic upregulation of CD40 and CD40 ligand mRNA expression in multiple sclerosis. Mult.Scler. 2000;6:61-65. (Link)

    Denton,M.D.; Reul,R.M.; Dharnidharka,V.R.; Fang,J.C.; Ganz,P.; Briscoe,D.M.. Central role for CD40/CD40 ligand (CD154) interactions in transplant rejection. Pediatr.Transplant. 1998;2:6-15. (Link)

    Mach,F.; Schonbeck,U.; Libby,P.. CD40 signaling in vascular cells: a key role in atherosclerosis?. Atherosclerosis 1998;137 Suppl:S89-S95. (Link)

    Szabolcs,M.J.; Cannon,P.J.; Thienel,U.; Chen,R.; Michler,R.E.; Chess,L.; Yellin,M.J.. Analysis of CD154 and CD40 expression in native coronary atherosclerosis and transplant associated coronary artery disease. Virchows Arch. 2000;437:149-159. (Link)

    Smith,T.J.; Sciaky,D.; Phipps,R.P.; Jennings,T.A.. CD40 expression in human thyroid tissue: evidence for involvement of multiple cell types in autoimmune and neoplastic diseases 114. Thyroid 1999;9:749-755. (Link)

    Eliopoulos,A.G.; Davies,C.; Knox,P.G.; Gallagher,N.J.; Afford,S.C.; Adams,D.H.; Young,L.S.. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol.Cell Biol. 2000;20:5503-5515. (Link)

    Lenkei,R.; Bratt,G.; Holmberg,V.; Muirhead,K.; Sandstrom,E.. Indicators of T-cell activation: correlation between quantitative CD38 expression and soluble CD8 levels in asymptomatic HIV+ individuals and healthy controls. Cytometry 1998;33:115-122. (Link)

    Posner,M.R.; Cavacini,L.A.; Upton,M.P.; Tillman,K.C.; Gornstein,E.R.; Norris,C.M.,Jr.. Surface membrane-expressed CD40 is present on tumor cells from squamous cell cancer of the head and neck in vitro and in vivo and regulates cell growth in tumor cell lines. Clin.Cancer Res. 1999;5:2261-2270. (Link)

    Propst,S.M.; Denson,R.; Rothstein,E.; Estell,K.; Schwiebert,L.M.. Proinflammatory and Th2-derived cytokines modulate CD40-mediated expression of inflammatory mediators in airway epithelia: implications for the role of epithelial CD40 in airway inflammation. J.Immunol. 2000;165:2214-2221. (Link)

    Laman,J.D.; De,Boer M.; Hart,B.A.. CD40 in clinical inflammation: from multiple sclerosis to atherosclerosis. Dev.Immunol. 1998;6:215-222. (Link)

    Klaus,G.G.; Choi,M.S.; Lam,E.W.; Johnson-Leger,C.; Cliff,J.. CD40: a pivotal receptor in the determination of life/death decisions in B lymphocytes. Int.Rev.Immunol. 1997;15:5-31. (Link)

    Larsen,C.P.; Pearson,T.C.. The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr.Opin.Immunol. 1997;9:641-647. (Link)

    Sugiura,T.; Kawaguchi,Y.; Harigai,M.; Takagi,K.; Ohta,S.; Fukasawa,C.; Hara,M.; Kamatani,N.. Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production. J.Immunol. 2000;164:6593-6600. (Link)

    Sabel,M.S.; Yamada,M.; Kawaguchi,Y.; Chen,F.A.; Takita,H.; Bankert,R.B.. CD40 expression on human lung cancer correlates with metastatic spread. Cancer Immunol.Immunother. 2000;49:101-108. (Link)

    Sugimoto,K.; Shiraki,K.; Ito,T.; Fujikawa,K.; Takase,K.; Tameda,Y.; Moriyama,M.; Nakano,T.. Expression of functional CD40 in human hepatocellular carcinoma. Hepatology 1999;30:920-926. (Link)
    Storage +4C