Serving Australia and NZ
1300 543 373
Return to Previous Page

Mouse TGF beta 1 Recombinant Protein Carrier-Free 100 ug

Mouse TGF beta 1 Recombinant Protein Carrier-Free 100 ug

Quick Overview:

Mouse TGF beta 1 Recombinant Protein Carrier-Free 100 ug

Product Code: 34-8342-82

  • Details

    Mouse TGF beta 1 (Transforming Growth Factor beta 1) is a member of a superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. Human TGF beta 1 is a 25 kDa protein with each subunit containing 112 aa residues. TGF beta 1 is secreted from the many cell types in a complex with LAP (Latency Associated Peptide) and also with LTBP (latent TGF beta binding protein). Disassociation is thought to happen in the extracellular matrix via proteases and/or integrins. Regulatory T cells are a recently identified source of TGF beta 1 thought to be a key player in their suppressive functions. TGF beta 1 binds through TGF beta receptors (of which there is a large family). The protein is highly conserved across all mammalian species.
  • Additional Information

    SKU 34-8342-82
    Name Mouse TGF beta 1 Recombinant Protein Carrier-Free 100 ug
    Size 100 ug
    Product Type Functional, Purified & Recombs
    Datasheet View Datasheet
    Supplier eBioscience
    Applications Cell Culture, Functional Assays
    Species reactivity (expected) Mouse
    General Readings Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013 Mar 6

    Shi G, Lovaas JD, Tan C, Vistica BP, Wawrousek EF, Aziz MK, Rigden RC, Caspi RR, Gery I.Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment. J Immunol. 2012 Aug 1;189(3):1220-7

    Derynck R, Jarrett JA, Chen EY, Goeddel DV. The murine transforming growth factor-beta precursor. J Biol Chem. 1986 Apr 15;261(11):5003-9.

    Frolik CA, Dart LL, Meyers CA, Smith DM, Sporn MB. Purification and initial characterization of a type beta transforming growth factor from human placenta. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3676-80.
    Storage -80C
    Purity Greater than 95%, as determined by SDS-PAGE